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Review
. 2016 Sep;16(9):67.
doi: 10.1007/s11882-016-0648-z.

MicroRNAs in Allergic Disease

Eishika Dissanayake  1 , Yuzaburo Inoue  2
Affiliations
Review

MicroRNAs in Allergic Disease

Eishika Dissanayake et al. Curr Allergy Asthma Rep. 2016 Sep.

Abstract

Purpose of review: MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs that are increasingly being recognized as important epigenetic regulators. They have been implicated in the pathogenesis of many diseases including cancer, cardiovascular diseases, connective tissue diseases, and neuromuscular disorders.

Recent findings: A few miRNAs have already been recognized as a core set of miRNAs important in allergic inflammation. These include let-7, miR-21, miR-142, and miR-146. This review aims to bring together some of the recent findings on how miRNAs regulate allergic inflammation with special focus on asthma, atopic dermatitis, allergic rhinitis, and eosinophilic esophagitis. We will also touch upon extracellular miRNAs and future perspective of this field of study.

Keywords: Allergic rhinitis; Asthma; Atopic dermatitis; Eosinophilic esophagitis; Inflammation; microRNAs.

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