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. 2016 Sep 1;17(1):62.
doi: 10.1186/s12881-016-0325-z.

PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men

Urban Alehagen  1   2 , Renate S Olsen  3   4 , Toste Länne  3   5 , Andreas Matussek  4 , Dick Wågsäter  3   6
Affiliations

PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men

Urban Alehagen et al. BMC Med Genet. .

Abstract

Background: Platelet-derived growth factor (PDGF) D has been reported to be active in fibroblasts, and in areas of myocardial infarction. In this longitudinal study we evaluated the association between PDGF-D polymorphism and cardiovascular mortality, and attempted to discover whether specific genotype differences regarding risk could be observed, and if gender differences could be seen.

Methods: Four hundred seventy-six elderly community participants were included in this study. All participants underwent a clinical examination, echocardiography, and blood sampling including PDGF-D single nucleotide polymorphism (SNP) analyses of the rs974819 A/A, G/A and G/G SNP. The follow-up time was 6.7 years.

Results: No specific genotype of rs974819 demonstrated increased cardiovascular mortality in the total population, however, the male group with genotypes A/A and G/A demonstrated an increased risk that persisted in a multivariate evaluation where adjustments were made for well-known cardiovascular risk factors (2.7 fold compared with the G/G genotype). No corresponding finding was observed in the female group.

Conclusion: We report here for the first time that the genotypes G/A or A/A of the SNP rs974819 near PDGF-D exhibited a 2.7 fold increased cardiovascular mortality risk in males. Corresponding increased risk could not be observed in either the total population and thus not in the female group. However, the sample size is was small and the results should be regarded as hypothesis-generating, and thus more research in the field is recommended.

Keywords: Cardiovascular risk; Gender; Genotypes; PDGF-D; Prognosis; rs974819.

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Figures

Fig. 1
Fig. 1
Kaplan-Meier graph illustrating cardiovascular mortality distributed into the genotypes G/G, G/A, and A/A of the SNP rs974819 in the total study population during 80 months of follow-up. Note: Censored participants were those still living at the end of the study period, or who had died of reasons other than cardiovascular disease. Completed participants were those who had died due to cardiovascular disease
Fig. 2
Fig. 2
Kaplan-Meier graph illustrating cardiovascular mortality distributed into the G/A or A/A genotypes combined compared to the G/G genotype of the SNP rs974819 in the male population during 80 months of follow-up. Note: Censored participants were those still living at the end of the study period, or who had died of reasons other than cardiovascular disease. Completed participants were those who had died due to cardiovascular disease
Fig. 3
Fig. 3
Kaplan-Meier graph illustrating cardiovascular mortality distributed into the G/A or A/A genotypes combined compared to the G/G genotype of the SNP rs974819 in the female population during 80 months of follow-up. Note: Censored participants were those still living at the end of the study period, or who had died of reasons other than cardiovascular disease. Completed participants were those who had died due to cardiovascular disease
See this image and copyright information in PMC

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