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. 2016 Oct;101(2):201-206.
doi: 10.1016/j.yexmp.2016.08.002. Epub 2016 Aug 29.

Alcoholic steatohepatitis (ASH) causes more UPR-ER stress than non-alcoholic steatohepatitis (NASH)

M Masouminia  1 , S Samadzadeh  2 , A Ebaee  3 , B A French  4 , B Tillman  5 , S W French  6
Affiliations

Alcoholic steatohepatitis (ASH) causes more UPR-ER stress than non-alcoholic steatohepatitis (NASH)

M Masouminia et al. Exp Mol Pathol. 2016 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Cross reaction of cytoprotective pathways and cell death pathways under ER stress
Fig. 2
Fig. 2
PERK in ASH and NASH were significantly upregulated (p < 0.05) compared to the Controls. The expressions of PERK tend to be elevated in NASH in comparison to ASH. (×690)
Fig. 3
Fig. 3
The double stain for PERK and UB is shown (A, B). Colocalization of PERK and UB is seen within the Mallory body (C). Also shown is an increase in the fluorescent intensity in the adjacent liver cells. (×520)
Fig. 4
Fig. 4
IRE-1α expression in NASH was significantly (p < 0.05) elevated compared to controls and tend to be elevated in comparison to ASH. IRE-1α expressions in ASH tend to be increased compared to the controls. The yellow tracer line converted the fluorecence intensity in to the green line in the graph. (×690)
Fig. 5
Fig. 5
ATF6 expressions in ASH tend to be increased compared to Controls and NASH. Its expression in NASH was decreased in comparison to the controls. (×690)
Fig. 6
Fig. 6
The expression of ATF4 in NASH was significantly (p < 0.05) downregulated compared to the controls. Its expression in ASH tended to be elevated in comparison to NASH. (×690)
Fig. 7
Fig. 7
The expression of BAX in ASH with the presence of MDB tended to be elevated in comparison to the controls and ASH without MDB.
See this image and copyright information in PMC

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