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Editorial
. 2016 Sep 2;119(6):701-3.
doi: 10.1161/CIRCRESAHA.116.309584.

Bone Marrow Takes Center Stage in Cardiovascular Disease

Filip K Swirski  1 , Matthias Nahrendorf  2
Affiliations
Editorial

Bone Marrow Takes Center Stage in Cardiovascular Disease

Filip K Swirski et al. Circ Res. .
No abstract available

Keywords: Editorials; atherosclerosis; cell proliferation; diabetes mellitus; myelopoiesis; thrombosis.

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Conflict of interest statement

Section The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Proposed mechanism for how LNK/SH2B3 attenuates cardiovascular disease
The authors show that, in the context of hypercholesterolemia, LNK/SH2B3 limits myelopoisis and platelet activation. Consequently, reduced LNK/SH2B3 might confer risk of coronary artery disease via both increased production of myeloid cells, which then accumulate in growing atherosclerotic lesions, and overabundantactivated platelets, which promote thrombosis.
See this image and copyright information in PMC

Comment on

References

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