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Meta-Analysis
. 2016 Sep;77(5):676-80.
doi: 10.15288/jsad.2016.77.676.

Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics

Arpana Agrawal  1 , Howard J Edenberg  2 , Joel Gelernter  3   4
Affiliations
Meta-Analysis

Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics

Arpana Agrawal et al. J Stud Alcohol Drugs. 2016 Sep.

Abstract

Meta-analyses of genome-wide association study data have begun to lead to promising new discoveries for behavioral and psychiatrically relevant phenotypes (e.g., schizophrenia, educational attainment). We outline how this methodology can similarly lead to novel discoveries in genomic studies of substance use disorders, and discuss challenges that will need to be overcome to accomplish this goal. We illustrate our approach with the work of the newly established Substance Use Disorders workgroup of the Psychiatric Genomics Consortium.

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References

    1. Agrawal A., Verweij K. J., Gillespie N. A., Heath A. C., Lessov-Schlaggar C. N., Martin N. G., Lynskey M. T. The genetics of addiction—A translational perspective. Translational Psychiatry. 2012;2:e140. doi:10.1038/tp.2012.54. - PMC - PubMed
    1. Bierut L. J., Goate A. M., Breslau N., Johnson E. O., Bertelsen S., Fox L., Edenberg H. J. ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Molecular Psychiatry. 2012;17:445–450. doi:10.1038/mp.2011.124. - PMC - PubMed
    1. Chassin L., Sher K. J., Hussong A., Curran P. The developmental psychopathology of alcohol use and alcohol disorders: Research achievements and future directions. Development and Psychopathology. 2013;25:1567–1584. doi:10.1017/S0954579413000771. - PMC - PubMed
    1. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. The Lancet. 2013;381:1371–1379. doi:10.1016/S0140-6736(12)62129-1. - PMC - PubMed
    1. Derringer J., Corley R. P., Haberstick B. C., Young S. E., Demmitt B. A., Howrigan D. P., McQueen M. B. Genome-wide association study of behavioral disinhibition in a selected adolescent sample. Behavior Genetics. 2015;45:375–381. doi:10.1007/s10519-015-9705-y. - PMC - PubMed

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