Finding DNA Ends within a Haystack of Chromatin
- PMID: 27588600
- DOI: 10.1016/j.molcel.2016.08.012
Finding DNA Ends within a Haystack of Chromatin
Abstract
Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to detect DNA breaks in vivo that can be adapted to various experimental and clinical settings.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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DNA Breaks and End Resection Measured Genome-wide by End Sequencing.Mol Cell. 2016 Sep 1;63(5):898-911. doi: 10.1016/j.molcel.2016.06.034. Epub 2016 Jul 28. Mol Cell. 2016. PMID: 27477910 Free PMC article.
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