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Comment
. 2016 Oct;23(10):1577-8.
doi: 10.1038/cdd.2016.82. Epub 2016 Sep 2.

Elementary: breast cancer culprits leave their signatures on the double helix

Delphine Merino  1   2 , Bhupinder Pal  1   2 , Anthony T Papenfuss  2   3
Affiliations
Comment

Elementary: breast cancer culprits leave their signatures on the double helix

Delphine Merino et al. Cell Death Differ. 2016 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Identification of new somatic mutations and related mutational signatures in 560 breast cancer patients. The beauty of the analysis of Nik-Zainal et al. is that it goes beyond looking for recurrent mutations in protein coding regions of genes, and examines the patterns of mutations in intronic and intergenic regions. They found that various processes such as APOBEC-mediated DNA editing, p53, BRCA1/2 mutations or Kataegis mediated hypermutation can leave footprints in the genome. BC, breast cancer; RS, rearrangement signatures; S, substitution; TNBC, triple negative breast cancer
See this image and copyright information in PMC

Comment on

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
    Nik-Zainal S, Davies H, Staaf J, Ramakrishna M, Glodzik D, Zou X, Martincorena I, Alexandrov LB, Martin S, Wedge DC, Van Loo P, Ju YS, Smid M, Brinkman AB, Morganella S, Aure MR, Lingjærde OC, Langerød A, Ringnér M, Ahn SM, Boyault S, Brock JE, Broeks A, Butler A, Desmedt C, Dirix L, Dronov S, Fatima A, Foekens JA, Gerstung M, Hooijer GK, Jang SJ, Jones DR, Kim HY, King TA, Krishnamurthy S, Lee HJ, Lee JY, Li Y, McLaren S, Menzies A, Mustonen V, O'Meara S, Pauporté I, Pivot X, Purdie CA, Raine K, Ramakrishnan K, Rodríguez-González FG, Romieu G, Sieuwerts AM, Simpson PT, Shepherd R, Stebbings L, Stefansson OA, Teague J, Tommasi S, Treilleux I, Van den Eynden GG, Vermeulen P, Vincent-Salomon A, Yates L, Caldas C, van't Veer L, Tutt A, Knappskog S, Tan BK, Jonkers J, Borg Å, Ueno NT, Sotiriou C, Viari A, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Birney E, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Stratton MR. Nik-Zainal S, et al. Nature. 2016 Jun 2;534(7605):47-54. doi: 10.1038/nature17676. Epub 2016 May 2. Nature. 2016. PMID: 27135926 Free PMC article.

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