Advanced Technologies Lead iNto New Reprogramming Routes

Yang Zhou¹, Li Qian²

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: li_qian@med.unc.edu.

PMID: 27588744
DOI: 10.1016/j.stem.2016.08.014

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Advanced Technologies Lead iNto New Reprogramming Routes

Yang Zhou et al. Cell Stem Cell. 2016.

Free article

. 2016 Sep 1;19(3):286-8.

doi: 10.1016/j.stem.2016.08.014.

Authors

Yang Zhou¹, Li Qian²

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: li_qian@med.unc.edu.

PMID: 27588744
DOI: 10.1016/j.stem.2016.08.014

Abstract

Two recent papers provide new insights on transcriptional dynamics and epigenetic remodeling during reprogramming of induced neurons (iNs). Treutlein et al. (2016) applied single-cell transcriptomics to identify routes and detours during early iN induction, while in this issue of Cell Stem Cell, Black et al. (2016) employed gene editing to activate endogenous loci of the reprogramming factors.

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Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq.
Treutlein B, Lee QY, Camp JG, Mall M, Koh W, Shariati SA, Sim S, Neff NF, Skotheim JM, Wernig M, Quake SR. Treutlein B, et al. Nature. 2016 Jun 16;534(7607):391-5. doi: 10.1038/nature18323. Epub 2016 Jun 8. Nature. 2016. PMID: 27281220 Free PMC article.
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.
Black JB, Adler AF, Wang HG, D'Ippolito AM, Hutchinson HA, Reddy TE, Pitt GS, Leong KW, Gersbach CA. Black JB, et al. Cell Stem Cell. 2016 Sep 1;19(3):406-14. doi: 10.1016/j.stem.2016.07.001. Epub 2016 Aug 11. Cell Stem Cell. 2016. PMID: 27524438 Free PMC article.

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Advanced Technologies Lead iNto New Reprogramming Routes

Affiliations

Advanced Technologies Lead iNto New Reprogramming Routes

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Grants and funding

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