Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Sep 13;113(37):10228-30.
doi: 10.1073/pnas.1612432113. Epub 2016 Sep 1.

Cutting back on the carbs

Vivian H Trang  1 , Peter D Senter  2
Affiliations
Comment

Cutting back on the carbs

Vivian H Trang et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Interactions of sialylated glycans with proteins. (A) Crystal structure of Siglec-7 associated with a sialylated ligand (Protein Data Bank ID code 2DF3) (28). (B) Cancer cells containing sialylated glycans can bind to Siglec and disrupt binding of NKG2D with its ligand potentially to inactivate NK cell killing. Desialylation can reverse the protective role of sialic acid.
See this image and copyright information in PMC

Comment on

References

    1. Ghazarian H, Idoni B, Oppenheimer SB. A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics. Acta Histochem. 2011;113(3):236–247. - PMC - PubMed
    1. Pinho SS, Reis CA. Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer. 2015;15(9):540–555. - PubMed
    1. Spiro RG. Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds. Glycobiology. 2002;12(4):43R–56R. - PubMed
    1. Fernández-Tejada A, Cañada FJ, Jiménez-Barbero J. Recent developments in synthetic carbohydrate-based diagnostics, vaccines, and therapeutics. Chemistry Eur J. 2015;21(30):10616–10628. - PubMed
    1. Dicker M, Strasser R. Using glyco-engineering to produce therapeutic proteins. Expert Opin Biol Ther. 2015;15(10):1501–1516. - PMC - PubMed

LinkOut - more resources