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Comparative Study
. 2016 Dec 13;7(50):83767-83774.
doi: 10.18632/oncotarget.11765.

Impact of age on the survival of pediatric leukemia: an analysis of 15083 children in the SEER database

Yaping Wang  1 , Jie Huang  1 , Liucheng Rong  1 , Peng Wu  1 , Meiyun Kang  1 , Xuejie Zhang  1 , Qin Lu  1 , Yongjun Fang  1
Affiliations
Comparative Study

Impact of age on the survival of pediatric leukemia: an analysis of 15083 children in the SEER database

Yaping Wang et al. Oncotarget. .

Abstract

Background & aims: Age at diagnosis is a key factor for predicting the prognosis of pediatric leukemia especially regarding the survivorship assessment. In this study, we aimed to assess the impact of this prognostic factor such as age in children with pediatric leukemia.

Methods: In this study, Surveillance, Epidemiology, and End Results Program-registered children with leukemia during 1988-2013 were analyzed. All patients were divided into five groups according to the age at the time of diagnosis (<1, 1-4, 5-9, 10-15, >15 years old). Kaplan-Meier and multivariable Cox regression models were used to evaluate leukemia survival outcomes and risk factors.

Results: There was significant variability in pediatric leukemia survival by age at diagnosis including ALL, AML and CML subtypes. According to the survival curves in each group, survival rate were peaked among children diagnosed at 1-4 years and steadily declined among those diagnosed at older ages in children with ALL. Infants (<1 year) had the lowest survivorship in children with either ALL or AML. However, children (1-4 years) harbored the worst prognosis suffering from CML. A stratified analysis of the effect of age at diagnosis was validated as independent predictors for the prognosis of pediatric leukemia.

Conclusions: Age at diagnosis remained to be a crucial determinant of the survival variability of pediatric leukemia patients.

Keywords: Kaplan-Meier; age; epidemiology; leukemia; surveillance.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no financial conflict of interest

Figures

Figure 1
Figure 1. Kaplan-Meier pediatric leukemia survival estimates by age at diagnosis
A. ALL; B. AML; C. CML.
Figure 2
Figure 2. Survival curves of patients with pediatric leukemia in independent cohort set in different age groups
A. ALL; B. AML.
See this image and copyright information in PMC

References

    1. Lee P, Bhansali R, Izraeli S, Hijiya N, Crispino JD. The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with down syndrome. Leukemia. 2016 - PMC - PubMed
    1. Warris LT, van den Heuvel-Eibrink MM, Aarsen FK, Pluijm SM, Bierings MB, van den Bos C, Zwaan CM, Thygesen HH, Tissing WJ, Veening MA, Pieters R, van den Akker EL. Hydrocortisone as an Intervention for Dexamethasone-Induced Adverse Effects in Pediatric Patients With Acute Lymphoblastic Leukemia: Results of a Double-Blind, Randomized Controlled Trial. J Clin Oncol. 2016 - PubMed
    1. Miller TP, Li Y, Kavcic M, Troxel AB, Huang YS, Sung L, Alonzo TA, Gerbing R, Hall M, Daves MH, Horton TM, Pulsipher MA, Pollard JA, Bagatell R, Seif AE, Fisher BT, et al. Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia. J Clin Oncol. 2016;34:1537–1543. - PMC - PubMed
    1. Eidenschink Brodersen L, Alonzo TA, Menssen AJ, Gerbing RB, Pardo L, Voigt AP, Kahwash SB, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Loken MR. A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children's Oncology Group. Leukemia. 2016 - PMC - PubMed
    1. de Rooij JD, Masetti R, van den Heuvel-Eibrink MM, Cayuela JM, Trka J, Reinhardt D, Rasche M, Sonneveld E, Alonzo TA, Fornerod M, Zimmermann M, Pigazzi M, Pieters R, Meshinchi S, Zwaan CM, Locatelli F. Recurrent genetic abnormalities can be used for risk-group stratification in pediatric AMKL: results of a retrospective intergroup study. Blood. 2016 - PMC - PubMed

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