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. 2016 Nov;35(11):1367-1370.
doi: 10.1016/j.healun.2016.07.014. Epub 2016 Jul 27.

Microscopic organizing pneumonia and cellular non-specific interstitial pneumonia are widespread in macroscopically normal-appearing lung tissue in idiopathic pulmonary fibrosis

Nevins W Todd  1 , Jeffrey R Galvin  2 , Ashutosh Sachdeva  3 , Irina G Luzina  4 , Sergei P Atamas  1 , Allen P Burke  5
Affiliations

Microscopic organizing pneumonia and cellular non-specific interstitial pneumonia are widespread in macroscopically normal-appearing lung tissue in idiopathic pulmonary fibrosis

Nevins W Todd et al. J Heart Lung Transplant. 2016 Nov.
No abstract available

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Conflict of interest statement

None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Histologic findings from macroscopically normal-appearing tissue from representative patients, with each hematoxylin and eosin horizontal pair representing low and high magnification images from a single patient. Two representative patients are shown in panels A and B and in C and D, with low magnification demonstrating preserved background lung architecture, numerous foci of organizing pneumonia (OP; arrows) but without cellular non-specific interstitial pneumonia (NSIP), and high magnification showing well-formed foci of OP approximately 400 to 1,000 μm in size. A third patient is shown in panels E and F, which demonstrate widespread cellular NSIP, with numerous inflammatory cells within alveolar septae 50 to 100 μm in thickness, and numerous foci of OP (arrows, inset). A fourth patient is shown in panels G and H, which demonstrate widespread cellular NSIP but without identifiable foci of OP. Panels I and J demonstrate intense α-smooth muscle actin staining of two representative foci of OP: panel I from the patient in panels A and B, and panel J from the patient in panels C and D.
See this image and copyright information in PMC

References

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