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Multicenter Study
. 2016 Sep 2;16(1):922.
doi: 10.1186/s12889-016-3602-z.

Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort

Sachiko Ono  1 , Yosuke Ono  2 , Hiroki Matsui  3 , Hideo Yasunaga  3
Affiliations
Multicenter Study

Factors associated with hospitalization for seasonal influenza in a Japanese nonelderly cohort

Sachiko Ono et al. BMC Public Health. .

Abstract

Background: Nonelderly patients may require hospitalization if their symptoms of influenza are severe. However, little evidence is available about the risk factors for hospitalization for influenza.

Methods: We used a multicenter outpatient and inpatient database to obtain patients' characteristics and clinical procedures. We identified patients aged <65 years with a confirmed diagnosis of influenza between October 2013 and December 2014. We used a Cox regression model to identify the risk factors for hospitalization, using a comparison group of individuals with a confirmed diagnosis of influenza but who were not hospitalized.

Results: Of 88,054 patients diagnosed with influenza, 276 (0.3 %) patients were hospitalized. With reference to patients aged 18-64 years, the hazard ratio (95 % confidence interval) for hospitalization in patients aged <2, 2-4, and 5-17 years was 12.25 (8.37-17.93), 4.56 (3.10-6.72) and 1.45 (1.03-2.05), respectively. Anemia, chronic obstructive pulmonary disease, neurologic disease, and regular steroid use were significantly associated with hospitalization. Hazard ratios were adjusted for age, sex, comorbidities, respiratory co-infection, virus type, and influenza season.

Conclusions: Our findings suggest that younger age and several comorbidities are associated with higher probability of hospitalization for influenza.

Keywords: Hospitalization; Nonelderly patient; Risk factor; Seasonal influenza.

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Figures

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Prescription patterns of neuraminidase inhibitors
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