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Review
. 2016 Oct;25(4):761-73.
doi: 10.1016/j.soc.2016.05.007. Epub 2016 Jul 30.

Liposarcoma: Multimodality Management and Future Targeted Therapies

Aimee M Crago  1 , Mark A Dickson  2
Affiliations
Review

Liposarcoma: Multimodality Management and Future Targeted Therapies

Aimee M Crago et al. Surg Oncol Clin N Am. 2016 Oct.

Abstract

There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.

Keywords: CDK4; FUS-CHOP; Liposarcoma; MDM2; Myxoid liposarcoma; Pleomorphic liposarcoma; Sarcoma; Trabectedin.

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Figures

Figure 1
Figure 1
MRI T1 images showing cross-sectional evaluation of (A) dedifferentiated liposarcoma in the hip and (B) well-differentiated liposarcoma in the thigh. Arrows show lipomatous components representing a well-differentiated component of the dedifferentiated tumor and the nodular high-grade component.
Figure 2
Figure 2
Flow-diagram delineating basic treatment algorithm used for management of patients with localized liposarcoma of the extremity.
See this image and copyright information in PMC

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MeSH terms