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Review
. 2016 Oct:20:40-46.
doi: 10.1016/j.coviro.2016.08.009. Epub 2016 Aug 31.

Human T-cell leukemia virus-associated malignancy

Amanda R Panfil  1 , Michael P Martinez  1 , Lee Ratner  2 , Patrick L Green  3
Affiliations
Review

Human T-cell leukemia virus-associated malignancy

Amanda R Panfil et al. Curr Opin Virol. 2016 Oct.

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a tumorigenic delta retrovirus and the causative infectious agent of a non-Hodgkin's peripheral T-cell malignancy called adult T-cell leukemia/lymphoma (ATL). ATL develops in approximately 5% of infected individuals after a significant clinical latency period of several decades. Clinical classifications of ATL include smoldering, chronic, lymphoma, and acute subtypes, with varying median survival ranges of a few months to several years. Depending on the ATL subtype and disease symptoms, treatment options include 'watchful waiting', chemotherapy, antiviral therapy, allogeneic hematopoietic stem cell transplantation (alloHSCT), and targeted therapies. Herein we review the characteristics and development of ATL, as well as current and future treatment options and perspectives.

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Figures

Figure 1
Figure 1
Transmission and development of ATL.
See this image and copyright information in PMC

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