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Comment
. 2016 Oct;24(10):774-776.
doi: 10.1016/j.tim.2016.08.005. Epub 2016 Sep 1.

Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic

Cason R King  1 , Tanner M Tessier  1 , Joe S Mymryk  2
Affiliations
Comment

Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic

Cason R King et al. Trends Microbiol. 2016 Oct.

Abstract

Viruses manipulate cellular chromatin to create a favourable milieu for infection. In several cases, virally-encoded proteins structurally mimic cellular histones to molecularly rewire the host cell. A recent study identified a novel mechanism whereby adenovirus protein VII, a viral histone, binds and manipulates host cell chromatin to suppress inflammatory signalling.

Keywords: HMGB1; adenovirus; chromatin; inflammation; protein VII; viral mimicry.

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  • A core viral protein binds host nucleosomes to sequester immune danger signals.
    Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD. Avgousti DC, et al. Nature. 2016 Jul 7;535(7610):173-7. doi: 10.1038/nature18317. Epub 2016 Jun 29. Nature. 2016. PMID: 27362237 Free PMC article.

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