Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May 19;8(4):460-469.
doi: 10.1080/21505594.2016.1222343. Epub 2016 Aug 11.

The global epidemiology of carbapenemase-producing Enterobacteriaceae

David van Duin  1 , Yohei Doi  2
Affiliations
Review

The global epidemiology of carbapenemase-producing Enterobacteriaceae

David van Duin et al. Virulence. .

Abstract

Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases). KPC-producing CPE are the most commonly occurring CPE in the United States. MBL-producing CPE have been most commonly associated with the Indian Subcontinent as well as with specific countries in Europe, including Romania, Denmark, Spain, and Hungary. The epicenter of OXA-48-like-producing is in Turkey and surrounding countries. Detailed knowledge of the epidemiology and molecular characteristics of CPE is essential to stem the spread of these pathogens.

Keywords: carbapenem-resistant Enterobacteriaceae; carbapenemases; epidemiology; global; plasmid.

PubMed Disclaimer

References

    1. Organization WH Antimicrobial Resistance: Global Report on Surveillance. 2014; http://wwwwhoint/drugresistance/documents/surveillancereport/en/
    1. Centers for Disease Control and Prevention ANTIBIOTIC RESISTANCE THREATS in the United States, 2013. 2013; http://wwwcdcgov/drugresistance/threat-report-2013/
    1. van Duin D, Paterson DL. Multidrug-resistant bacteria in the community: Trends and lessons learned. Infect Dis Clin North Am 2016; 30:377-90; PMID:27208764; https://doi.org/ 10.1016/j.idc.2016.02.004 - DOI - PMC - PubMed
    1. Khatri A, Naeger Murphy N, Wiest P, Osborn M, Garber K, Hecker M, Hurless K, Rudin SD, Jacobs MR, Kalayjian RC, et al.. Community-Acquired Pyelonephritis in Pregnancy Caused by KPC-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2015; 59:4375-8; PMID:26185273; https://doi.org/ 10.1128/AAC.00553-15 - DOI - PMC - PubMed
    1. van Duin D, Kaye KS, Neuner EA, Bonomo RA. Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn Microbiol Infect Dis 2013; 75:115-20; PMID:23290507; https://doi.org/ 10.1016/j.diagmicrobio.2012.11.009 - DOI - PMC - PubMed

Publication types

MeSH terms