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Comment
. 2016 Oct;24(10):771-772.
doi: 10.1016/j.tim.2016.08.003. Epub 2016 Sep 1.

Antibiotic Methylation: A New Mechanism of Antimicrobial Resistance

Kerri M Malone  1 , Stephen V Gordon  2
Affiliations
Comment

Antibiotic Methylation: A New Mechanism of Antimicrobial Resistance

Kerri M Malone et al. Trends Microbiol. 2016 Oct.

Abstract

In new research on Mycobacterium tuberculosis, the causative agent of tuberculosis, Warrier and colleagues have discovered a novel mode of bacterial drug resistance, namely antibiotic inactivation via N-methylation.

Keywords: Mycobacterium tuberculosis; TB; anti-TB drugs; antibiotic methylation; drug resistance; methyltransferase.

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  • N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
    Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF. Warrier T, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432954 Free PMC article.

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