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Comment
. 2016 Nov;32(11):687-688.
doi: 10.1016/j.tig.2016.08.007. Epub 2016 Sep 1.

A Universal Code for mRNA Stability?

Ying-Hsin Chen  1 , Jeff Coller  2
Affiliations
Comment

A Universal Code for mRNA Stability?

Ying-Hsin Chen et al. Trends Genet. 2016 Nov.

Abstract

Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.

Keywords: codon optimality; deadenylation; mRNA decay; maternal-to-zygotic transition; translation.

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Figures

Figure 1
Figure 1. Proposed model for Codon-mediated maternal mode decay
1. (A) In maternal mode decay, transcripts with non-optimal codons (Red) decay faster than those with optimal codons (Green) during MZT. (B) In zebrafish embryos, optimal codons have higher concentrations of corresponding tRNAs than non-optimal codons. (C) In maternal mode decay, codon optimality impacts mRNA stability in a translation-dependent manner and promotes deadenylation of non-optimal mRNAs by CCR4-NOT complex.
See this image and copyright information in PMC

Comment on

References

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