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Review
. 2016:2016:2981931.
doi: 10.1155/2016/2981931. Epub 2016 Aug 10.

Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics

Riccarda Antiochia  1 , Paolo Bollella  1 , Gabriele Favero  1 , Franco Mazzei  1
Affiliations
Review

Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics

Riccarda Antiochia et al. Int J Anal Chem. 2016.

Abstract

In the last decades, in vitro diagnostic devices (IVDDs) became a very important tool in medicine for an early and correct diagnosis, a proper screening of targeted population, and also assessing the efficiency of a specific therapy. In this review, the most recent developments regarding different configurations of surface plasmon resonance affinity biosensors modified by using several nanostructured materials for in vitro diagnostics are critically discussed. Both assembly and performances of the IVDDs tested in biological samples are reported and compared.

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Figures

Figure 1
Figure 1
Scheme of bulk SPR with (a) nanoparticles incorporated onto the surface and (b) sandwich “assay” with nanoparticles amplification.
Figure 2
Figure 2
Scheme of localized SPR by using metal nanoparticles as amplification system to improve the IVD devices thanks to the local electric field/surface plasmon interaction.
Figure 3
Figure 3
Scheme of SPR imaging.
See this image and copyright information in PMC

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