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Case Reports
. 2016 May 17;11(3):125-8.
doi: 10.1016/j.radcr.2016.04.012. eCollection 2016 Sep.

Extranodal manifestation of Rosai-Dorfman disease in the breast tissue

Qiao Zhou  1 , Umer Ansari  1 , Nandan Keshav  1 , Fiona Davis  2 , Maria Cundiff  2
Affiliations
Case Reports

Extranodal manifestation of Rosai-Dorfman disease in the breast tissue

Qiao Zhou et al. Radiol Case Rep. .

Abstract

A 71-year-old asymptomatic female with a history of breast cancer status after right total mastectomy had interval development of several new nodules in the left breast in a 1-year time span. Stereotactic biopsy was performed, which revealed multifocal Rosai Dorfman disease in the left breast. The patient was referred to hematology, and computed tomography of the chest/abdomen/pelvis did not demonstrate any lymphadenopathy elsewhere in the body. This case report discusses incidences of extranodal Rosai Dorfman disease and the differential for breast lesions that can present the same way.

Keywords: Breast; Histiocytes; Mammography; Rosai Dorfman disease.

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Figures

Fig. 1
Fig. 1
7/3/2014: Mammogram demonstrates no evidence of malignancy.
Fig. 2
Fig. 2
Mammogram 7/9/2015: 2 new nodules within the upper left breast, one at the 12:00 position and the other at the 1 to 2:00 position posteriorly.
Fig. 3
Fig. 3
At the 12:00 position 10 cm from the nipple, there is an oval parallel 5 × 3 × 5 mm3 mass with slightly irregular margins. At the 2:00 position 4 cm from the nipple, there is a 4 × 4 × 3 mm3 new hypoechoic nodule.
Fig. 4
Fig. 4
Immunoperoxidase stain panel performed on with results: s100 (A1 and C1) strongly positive in histiocytes; CD1a (A1) negative in histiocytes; CD138 (A1) highlights plasma cells; kappa (A1) and lambda (A1) fail to demonstrate evidence of clonality.
Fig. 5
Fig. 5
Hematoxylin and eosin stain shows well-demarcated infiltrates of prominent histiocytes intermixed with small mature lymphocytes and plasma cells. Histiocytes are large, irregularly shaped with abundant vacuolated cytoplasm. Engulfed lymphocytes as shown by a clear halo of cytoplasm surrounding lymphocytes is a characteristic of emperipolesis (arrow). Plasma cells demonstrate binucleation. Evidence of intact nodal architecture is not identified.
See this image and copyright information in PMC

References

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