Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016:2016:2389895.
doi: 10.1155/2016/2389895. Epub 2016 Aug 9.

Polydopamine-Assisted Surface Modification for Bone Biosubstitutes

Shishu Huang  1 , Nuanyi Liang  2 , Yang Hu  3 , Xin Zhou  2 , Noureddine Abidi  4
Affiliations
Review

Polydopamine-Assisted Surface Modification for Bone Biosubstitutes

Shishu Huang et al. Biomed Res Int. 2016.

Abstract

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The schematic formation of PDA coating layer [31].
Figure 2
Figure 2
Different monomer states during the polymerization of DA to form PDA layer [39].
See this image and copyright information in PMC

References

    1. Langer R., Vacanti J. P. Tissue engineering. Science. 1993;260(5110):920–926. doi: 10.1126/science.8493529. - DOI - PubMed
    1. Williams D. Benefit and risk in tissue engineering. Materials Today. 2004;7(5):24–29. doi: 10.1016/S1369-7021(04)00232-9. - DOI
    1. Williams D. F. The Williams Dictionary of Biomaterials. Liverpool, UK: Liverpool University Press; 1999.
    1. Burchill L. J., Ross H. J. Heart transplantation in adults with end-stage congenital heart disease. Future Cardiology. 2012;8(2):329–342. doi: 10.2217/fca.12.11. - DOI - PubMed
    1. Molzahn A. E., Starzomski R., McCormick J. The supply of organs for transplantation: issues and challenges. Nephrology Nursing Journal. 2003;30(1):17–28. - PubMed