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Review
. 2016 Sep;18(9):69.
doi: 10.1007/s11906-016-0676-z.

Renal Afferents

Alissa A Frame  1 , Casey Y Carmichael  1 , Richard D Wainford  2
Affiliations
Review

Renal Afferents

Alissa A Frame et al. Curr Hypertens Rep. 2016 Sep.

Abstract

Purpose of review: The etiology of hypertension, a critical public health issue affecting one in three US adults, involves the integration of the actions of multiple organ systems, including the renal sympathetic nerves. The renal sympathetic nerves, which are comprised of both afferent (sensory input) and efferent (sympathetic outflow) arms, have emerged as a major potential therapeutic target to treat hypertension and disease states exhibiting excess renal sympathetic activity.

Recent findings: This review highlights recent advances in both clinical and basic science that have provided new insight into the distribution, function, and reinnervation of the renal sympathetic nerves, with a focus on the renal afferent nerves, in hypertension and hypertension-evoked disease states including salt-sensitive hypertension, obesity-induced hypertension, and chronic kidney disease. Increased understanding of the differential role of the renal afferent versus efferent nerves in the pathophysiology of hypertension has the potential to identify novel targets and refine therapeutic interventions designed to treat hypertension.

Keywords: Hypertension; Radiofrequency ablation; Renal afferent nerves; Renal denervation; Renal efferent nerves; Sympathetic nervous system.

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Conflict of interest statement

Drs. Frame, Carmichael, and Wainford declare no conflicts of interest relevant to this manuscript. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.

References

    1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart Disease and Stroke Statistics—2016 Update: a report from the American Heart Association. Circulation. 2016;133(4):e38–360. doi: 10.1161/CIR.0000000000000350. - DOI - PubMed
    1. Johns EJ. Autonomic regulation of kidney function. Handb Clin Neurol. 2013;117:203–14. doi: 10.1016/B978-0-444-53491-0.00017-1. - DOI - PubMed
    1. Johns EJ, Abdulla MH. Renal nerves in blood pressure regulation. Curr Opin Nephrol Hypertens. 2013;22(5):504–10. doi: 10.1097/MNH.0b013e3283641a89. - DOI - PubMed
    1. Krum H, Schlaich MP, Sobotka PA, Bohm M, Mahfoud F, Rocha-Singh K, et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014;383(9917):622–9. doi: 10.1016/S0140-6736(13)62192-3. - DOI - PubMed
    1. Kopp UC. Role of renal sensory nerves in physiological and pathophysiological conditions. Am J Physiol Regul Integr Comp Physiol. 2015;308(2):R79–95. doi: 10.1152/ajpregu.00351.2014. - DOI - PMC - PubMed