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. 2017 Jan:49:214.e7-214.e11.
doi: 10.1016/j.neurobiolaging.2016.07.018. Epub 2016 Aug 5.

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

Valentina Escott-Price  1 , Maryam Shoai  2 , Richard Pither  3 , Julie Williams  4 , John Hardy  5
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Free article

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

Valentina Escott-Price et al. Neurobiol Aging. 2017 Jan.
Free article

Abstract

We estimate the maximum prediction accuracy for the risk of Alzheimer's disease based on disease prevalence and heritability of liability. We demonstrate that the recently reported AUC values for predicting of Alzheimer's disease using polygenic scores reach about 90% of the estimated maximum accuracy that can be achieved by predictors of genetic risk based on genomic profiles.

Keywords: AUC; Heritability; Polygenic score.

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