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Review
. 2016 Dec:21:75-80.
doi: 10.1016/j.coviro.2016.08.003. Epub 2016 Sep 3.

In vivo tissue-tropism of adeno-associated viral vectors

Arun Srivastava  1
Affiliations
Review

In vivo tissue-tropism of adeno-associated viral vectors

Arun Srivastava. Curr Opin Virol. 2016 Dec.

Abstract

In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented. The Subsequent discovery of a number of AAV serotypes, and attempts to identify the cellular receptors and co-receptors for these serotype vectors has had significant implications in their use in human gene therapy. As additional AAV serotypes are discovered and isolated, a detailed understanding of their tropism is certainly likely to play a key role in all future studies, both basic science as well as clinical.

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Figures

Figure 1
Figure 1. Schematic representation of the use of recombinant AAV serotype vectors in various animal models and in humans
Schematic representation of the most commonly used animal models for evaluating the efficacy and safety of recombinant AAV serotype vectors. Various routes of administration of AAV vectors to target various tissues and organs have been utilized. In several Phase I/II, and one Phase III, clinical trials in humans with various AAV serotype vectors to target the indicated organs are also depicted.
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