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. 2017 Mar 1;74(3):e85-e86.
doi: 10.1097/QAI.0000000000001174.

HIV and Hormonal Contraception: Bench and Bedside

Nirk E Quispe Calla  1 , Rodolfo D Vicetti Miguel, Wayne Trout, Thomas L Cherpes
Affiliations

HIV and Hormonal Contraception: Bench and Bedside

Nirk E Quispe Calla et al. J Acquir Immune Defic Syndr. .
No abstract available

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Conflict of interest statement

Authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1. LNG-IUS use increased permeability and decreased desmoglein-1 (DSG1) expression levels in human ectocervical mucosal tissue
Ectocervical biopsy specimens were obtained from 7 healthy young women at enrollment (i.e., using no form of hormonal contraception) and 1 month after LNG-IUS use was initiated. These specimens were used to define permeability to a fluorescently-tagged low molecular weight molecule and expression levels of the cell-cell adhesion molecule DSG1. (A) Representative images display increased permeability to Lucifer yellow CH, lithium salt (LY) with LNG-IUS use (L denotes vaginal lumen); (white bar = 20 μm); (LY, green); dextran Texas-Red (red); DAPI, 4,6-diamidino-2-phenylindole (blue). (B) LNG-IUS use significantly reduced DSG1 expression (panel displays relative gene expression levels before and after LNG-IUS insertion) (relative gene expression was defined using glucose-6-phosphate isomerase as a housekeeping reference gene); a paired Student t-test provided statistical comparison; p ≤ 0.05 were considered statistically significant.
See this image and copyright information in PMC

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References

    1. Polis CB, Curtis KM. Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence. Lancet Infect Dis. 2013;13:797–808. - PubMed
    1. Hickey M, Marino JL, Tachedjian G. Critical Review: Mechanisms of HIV Transmission in Depo-Provera Users: The Likely Role of Hypoestrogenism. J Acquir Immune Defic Syndr. 2016;71:1–7. - PubMed
    1. Quispe Calla, NE Vicetti, Miguel RD, Boyaka PN, et al. Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. Mucosal Immunol. 2016 doi: 10.1038/mi.2016.22. - DOI - PMC - PubMed
    1. Committee on Adolescent Health Care Long-Acting Reversible Contraception Working Group, The American College of Obstetricians and Gynecologists. Committee opinion no. 539: Adolescents and long-acting reversible contraception: implants and intrauterine devices. Obstet Gynecol. 2012;120:983–988. - PubMed
    1. Smith SM, Baskin GB, Marx PA. Estrogen protects against vaginal transmission of simian immunodeficiency virus. J Infect Dis. 2000;182:708–715. - PubMed

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