doi: 10.1016/j.it.2016.08.006.
Epub 2016 Sep 3.
Dengue Antibody and Zika: Friend or Foe?
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- PMID: 27599407
- DOI: 10.1016/j.it.2016.08.006
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Dengue Antibody and Zika: Friend or Foe?
Trends Immunol.
2016 Oct.
Abstract
Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on Zika infection, transmission, and clinical outcome. Discerning these effects is critical to a better understanding of Zika pathogenesis and the prevention of future outbreaks.
Keywords: Zika virus; antibody-dependent enhancement of infection; dengue virus.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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