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. 2017 Feb;21(1):29-36.
doi: 10.1007/s11030-016-9694-7. Epub 2016 Sep 6.

Efficient one-pot synthesis of new 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate esters via copper-free Sonogashira coupling reactions

Ali Keivanloo  1 , Shaghayegh Sadat Kazemi  2 , Hossein Nasr-Isfahani  2 , Abdolhamid Bamoniri  3
Affiliations

Efficient one-pot synthesis of new 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate esters via copper-free Sonogashira coupling reactions

Ali Keivanloo et al. Mol Divers. 2017 Feb.

Abstract

The reactions of several 2-chloroquinoline-3-carboxylate esters with propargyl alcohol and a secondary amine in the presence of palladium catalyst leads to the formation of new alkyl 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate derivatives. This one-pot process, carried out in the absence of any copper salt, provides an efficient method for the synthesis of functionalized pyrrolo[1,2-a]quinolines in good-to-high yields.

Keywords: Copper-free; Palladium catalyst; Propargyl alcohol; Pyrrolo[1,2-a]quinoline; Sonogashira coupling.

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