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. 2016 Jul;469(1):239-43.
doi: 10.1134/S1607672916040025. Epub 2016 Sep 7.

Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide

M M Yurinskaya  1   2 , S Y Funikov  2 , M B Evgen'ev  1   2 , M G Vinokurov  3
Affiliations

Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide

M M Yurinskaya et al. Dokl Biochem Biophys. 2016 Jul.

Abstract

The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.

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