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. 2016 Jul;469(1):264-8.
doi: 10.1134/S1607672916040086. Epub 2016 Sep 7.

mRNA expression profile of mouse oligodendrocytes in inflammatory conditions

A A Kudriaeva  1 , N A Khaustova  2 , D V Maltseva  2 , E S Kuzina  1 , I S Glagoleva  3 , E A Surina  1 , V D Knorre  4 , A A Belogurov Jr  1   3 , A G Tonevitsky  2 , A G Gabibov  1   3   5
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mRNA expression profile of mouse oligodendrocytes in inflammatory conditions

A A Kudriaeva et al. Dokl Biochem Biophys. 2016 Jul.

Abstract

In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.

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