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. 2016 Oct 21;60(11):6962-6964.
doi: 10.1128/AAC.01568-16. Print 2016 Nov.

Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing

Claire de Curraize  1   2 , Sylvain Kumanski  2 , Maïté Micaëlo  2   3   4 , Nelly Fournet  5 , Guy La Ruche  5 , Fabienne Meunier  2 , Rishma Amarsy  2   3   4 , Hervé Jacquier  2   3   4 , Emmanuelle Cambau  2   3   4 , Agathe Goubard  6 , Béatrice Bercot  7   3   4
Affiliations

Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing

Claire de Curraize et al. Antimicrob Agents Chemother. .

Abstract

Two extended-spectrum cephalosporin-resistant Neisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistant N. gonorrhoeae isolate harboring a penA mosaic; whole-genome sequencing highlighted an additional R251H substitution in the ftsX gene recently involved in cephalosporin resistance. The other, ceftriaxone-resistant isolate (MIC, 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to sequence type ST1579 (multilocus sequence typing [MLST]).

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