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. 2016 Sep 6;6(9):e012079.
doi: 10.1136/bmjopen-2016-012079.

PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique

Emma Barry  1 , Kirsty O'Brien  1 , Frank Moriarty  1 , Janine Cooper  2 , Patrick Redmond  1 , Carmel M Hughes  2 , Kathleen Bennett  1 , Tom Fahey  1 , Susan M Smith  1 ; PIPc Project Steering group
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PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique

Emma Barry et al. BMJ Open. .

Abstract

Objective: There is limited evidence regarding the quality of prescribing for children in primary care. Several prescribing criteria (indicators) have been developed to assess the appropriateness of prescribing in older and middle-aged adults but few are relevant to children. The objective of this study was to develop a set of prescribing indicators that can be applied to prescribing or dispensing data sets to determine the prevalence of potentially inappropriate prescribing in children (PIPc) in primary care settings.

Design: Two-round modified Delphi consensus method.

Setting: Irish and UK general practice.

Participants: A project steering group consisting of academic and clinical general practitioners (GPs) and pharmacists was formed to develop a list of indicators from literature review and clinical expertise. 15 experts consisting of GPs, pharmacists and paediatricians from the Republic of Ireland and the UK formed the Delphi panel.

Results: 47 indicators were reviewed by the project steering group and 16 were presented to the Delphi panel. In the first round of this exercise, consensus was achieved on nine of these indicators. Of the remaining seven indicators, two were removed following review of expert panel comments and discussion of the project steering group. The second round of the Delphi process focused on the remaining five indicators, which were amended based on first round feedback. Three indicators were accepted following the second round of the Delphi process and the remaining two indicators were removed. The final list consisted of 12 indicators categorised by respiratory system (n=6), gastrointestinal system (n=2), neurological system (n=2) and dermatological system (n=2).

Conclusions: The PIPc indicators are a set of prescribing criteria developed for use in children in primary care in the absence of clinical information. The utility of these criteria will be tested in further studies using prescribing databases.

Keywords: Delphi method; children; explicit criteria; potentially inappropriate prescribing; prescribing indicators.

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Figure 1
Figure 1
Flow diagram potentially inappropriate prescribing in children (PIPc) Study.
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