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Case Reports
. 2016 May-Aug;20(2):330.
doi: 10.4103/0973-029X.185908.

Juvenile nasopharyngeal angiofibroma

Jashika Adil Shroff Makhasana  1 , Meena A Kulkarni  2 , Suhas Vaze  3 , Adil Sarosh Shroff  4
Affiliations
Case Reports

Juvenile nasopharyngeal angiofibroma

Jashika Adil Shroff Makhasana et al. J Oral Maxillofac Pathol. 2016 May-Aug.

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive neoplasm and shows a propensity for destructive local spread often extending to the base of the skull and into the cranium. Clinically, however, it is obscure with painless, progressive unilateral nasal obstruction being the common presenting symptom with or without epistaxis and rhinorrhea. Diagnosis of JNA is made by complete history, clinical examination, radiography, nasal endoscopy and by using specialized imaging techniques such as arteriography, computer tomography and magnetic resonance imaging. Histopathology reveals a fibrocellular stroma with spindle cells and haphazard arrangement of collagen interspersed with an irregular vascular pattern. A case report of JNA with rare intra-oral manifestation in a 17-year-old male patient is presented in the article. JNA being an aggressive tumor may recur posttreatment. Thus, early diagnosis, accurate staging, and adequate treatment are essential in the management of this lesion.

Keywords: Androgen receptor; juvenile angiofiborma; nasopharyngeal angiofibroma.

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Figures

Figure 1
Figure 1
Intraoral view showing swelling on the upper left side of the maxilla and obliteration of the vestibule
Figure 2
Figure 2
Sagittal section in computed tomography scans showing site and extent of the lesion
Figure 3
Figure 3
Axial section in computed tomography demonstrating obliteration of the nasal cavity and maxillary sinus
Figure 4
Figure 4
Gross specimen showing tumor mass with vascular areas
Figure 5
Figure 5
Photomicrograph showing fibrocellular stroma and numerous blood vessels at the periphery (H&E stain, ×40)
Figure 6
Figure 6
Photomicrograph showing a staghorn appearance of the blood vessels (H&E stain, ×100)
Figure 7
Figure 7
Distribution of mast cells in the lesion (Toluidine blue stain, ×40)
See this image and copyright information in PMC

References

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