Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug 23:7:135.
doi: 10.3389/fneur.2016.00135. eCollection 2016.

New Treatments for Spinal Nerve Root Avulsion Injury

Thomas Carlstedt  1
Affiliations

New Treatments for Spinal Nerve Root Avulsion Injury

Thomas Carlstedt. Front Neurol. .

Erratum in

Abstract

Further progress in the treatment of the longitudinal spinal cord injury has been made. In an inverted translational study, it has been demonstrated that return of sensory function can be achieved by bypassing the avulsed dorsal root ganglion neurons. Dendritic growth from spinal cord sensory neurons could replace dorsal root ganglion axons and re-establish a reflex arch. Another research avenue has led to the development of adjuvant therapy for regeneration following dorsal root to spinal cord implantation in root avulsion injury. A small, lipophilic molecule that can be given orally acts on the retinoic acid receptor system as an agonist. Upregulation of dorsal root ganglion regenerative ability and organization of glia reaction to injury were demonstrated in treated animals. The dual effect of this substance may open new avenues for the treatment of root avulsion and spinal cord injuries.

Keywords: adjuvant therapy; nerve plexus; neurotization; root avulsion; sensory recovery; spinal cord regeneration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Carlstedt T. Perspective on the treatment of the longitudinal spinal cord injury. Front Neurol (2011) 2:11.10.3389/fneur.2010.00011 - DOI - PMC - PubMed
    1. Bergerot A, Shortland PJ, Annand P, Hunt SP, Carlstedt T. Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury. Exp Neurol (2004) 187:359–66.10.1016/j.expneurol.2004.02.003 - DOI - PubMed
    1. Chew DJ, Linster VHL, Sakthithasan M, Robson ML, Carlstedt T, Shortland PJ. Cell death after dorsal root injury. Neurosci Lett (2008) 433:231–4.10.1016/j.neulet.2008.01.012 - DOI - PubMed
    1. Hoang TX, Akhavan M, Wu J, Havton LA. Minocyline protects motor but not autonomic neurons after cauda equina injury. Exp Brain Res (2008) 187:71–7.10.1007/s00221-008-1398-5 - DOI - PMC - PubMed
    1. Carlstedt T. Central Nerve Plexus Injury. London: Imperial College Press; (2007).

LinkOut - more resources