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. 2016 Sep;12(3):1779-1782.
doi: 10.3892/ol.2016.4903. Epub 2016 Jul 22.

HPV strain distribution in patients with genital warts in a female population sample

Daniel Boda  1 , Monica Neagu  2 , Carolina Constantin  3 , Razvan Nicolae Voinescu  4 , Constantin Caruntu  5 , Sabina Zurac  6 , Demetrios A Spandidos  7 , Nikolaos Drakoulis  8 , Dimitrios Tsoukalas  9 , Aristides M Tsatsakis  9
Affiliations

HPV strain distribution in patients with genital warts in a female population sample

Daniel Boda et al. Oncol Lett. 2016 Sep.

Abstract

The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts. We found differences in the distribution of high-/low-risk strains and the incidence of high-risk strains was found to occur mainly in females under 35 years of age. The data from our study suggest that a detailed oral, rectal and genital identification of high-risk strains should be performed to visualize the entire pattern of possible triggers of carcinogenesis.

Keywords: HPV genotyping; carcinogenesis; cervical cancer; genital warts.

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Figures

Figure 1.
Figure 1.
Human papillomavirus (HPV) strain distribution in the investigated study population: percentage of strain type reported in all cases investigated.
Figure 2.
Figure 2.
Age distribution in the investigated group in terms of high/low and negative strain identification.
Figure 3.
Figure 3.
Age distribution among human papillomavirus high-risk strains.
See this image and copyright information in PMC

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