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. 2016 Sep;5(3):283-288.
doi: 10.3892/br.2016.720. Epub 2016 Jul 18.

Potential role of bromelain in clinical and therapeutic applications

Vidhya Rathnavelu  1 , Noorjahan Banu Alitheen  2 , Subramaniam Sohila  3 , Samikannu Kanagesan  4 , Rajendran Ramesh  5
Affiliations

Potential role of bromelain in clinical and therapeutic applications

Vidhya Rathnavelu et al. Biomed Rep. 2016 Sep.

Abstract

Pineapple has been used as part of traditional folk medicine since ancient times and it continues to be present in various herbal preparations. Bromelain is a complex mixture of protease extracted from the fruit or stem of the pineapple plant. Although the complete molecular mechanism of action of bromelain has not been completely identified, bromelain gained universal acceptability as a phytotherapeutic agent due to its history of safe use and lack of side effects. Bromelain is widely administered for its well-recognized properties, such as its anti-inflammatory, antithrombotic and fibrinolytic affects, anticancer activity and immunomodulatory effects, in addition to being a wound healing and circulatory improvement agent. The current review describes the promising clinical applications and therapeutic properties of bromelain.

Keywords: anti-microbial; anticancer; bromelain; inflammation; pineapple; therapeutics.

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References

    1. Morton J. Fruits of Warm Climates. Julia F. Morton; Miami, FL: 1987. Pineapple; pp. 18–28.
    1. Scopes RK. Protein Purification: Principles and Practice. 2nd. Springer-Verlag; New York, NY: 1982. pp. 41–65.
    1. Arnon R, Shapira E. Antibodies to papain. A selective fractionation according to inhibitory capacity. Biochemistry. 1967;6:3942–3950. doi: 10.1021/bi00864a041. - DOI - PubMed
    1. Ota S, Moore S, Stein WH. Preparation and chemical properties of purified stem and fruit bromelains. Biochemistry. 1964;3:180–185. doi: 10.1021/bi00890a007. - DOI - PubMed
    1. Murachi T, Yasui M, Yasuda Y. Purification and physical characterization of stem bromelain. Biochemistry. 1964;3:48–55. doi: 10.1021/bi00889a009. - DOI - PubMed