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Comment
. 2016 Sep 6;111(5):900-1.
doi: 10.1016/j.bpj.2016.07.031.

Force Bistability in Adhesion Switch

Michael L Dustin  1 , Christopher G Peel  2
Affiliations
Comment

Force Bistability in Adhesion Switch

Michael L Dustin et al. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Force bistability. The axis arrows reflect the direction of increase in the parameters: force, E-cadherin density, and activation (vinculin binding). The head-to-tail orientation of the axes signifies the proposed sequence of events in active nucleation-force application, E-cadherin clustering, and α-catenin activation. Once the cluster is formed, the force can be relaxed with retention of activation. The model is drawn to allow for a role of force in cluster dissolution. (Green arrows) Pathways to active states; (red arrow) pathway to eliminate the junction.
See this image and copyright information in PMC

Comment on

References

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