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Comment
. 2016 Sep 6;24(9):1435-6.
doi: 10.1016/j.str.2016.08.003.

A New Phase in ALS Research

P Andrew Chong  1 , Julie D Forman-Kay  2
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Free article
Comment

A New Phase in ALS Research

P Andrew Chong et al. Structure. .
Free article

Abstract

In this issue of Structure, Conicella et al. (2016) present evidence that the low complexity C-terminal region of TDP-43 undergoes liquid-liquid phase separation. ALS-associated mutations alter this phase separation process, providing a possible mechanism for the pathology caused by these TDP-43 mutations. The work is strongly supportive of toxic loss of RNA processing function in ALS.

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