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Review
. 2016 Dec;11(6):528-536.
doi: 10.1007/s11899-016-0346-x.

Acute Myeloid Leukemia: How Do We Measure Success?

Joshua P Sasine  1 , Gary J Schiller  2
Affiliations
Review

Acute Myeloid Leukemia: How Do We Measure Success?

Joshua P Sasine et al. Curr Hematol Malig Rep. 2016 Dec.

Abstract

The development and approval of novel, effective therapies for acute myeloid leukemia (AML) has lagged behind other malignancies. Judging success of therapy with meaningful endpoints is critical to development of new treatments. Overall survival (OS) has typically been the parameter necessary for regulatory approval of experimental therapy in AML. Herein, we discuss different strategies to define outcomes for patients with AML and their relative challenges.

Keywords: Acute myeloid leukemia; Event-free survival; Overall survival; Therapy.

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References

    1. Lancet Oncol. 2010 Nov;11(11):1029-35 - PubMed
    1. Leukemia. 2016 Jul;30(7):1456-64 - PubMed
    1. N Engl J Med. 2012 Mar 1;366(9):787-98 - PubMed
    1. Leukemia. 2013 Oct;27(10):2086-91 - PubMed
    1. Exp Hematol. 2016 May;44(5):363-377.e5 - PubMed

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