Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes
- PMID: 2760495
- DOI: 10.1093/infdis/160.3.380
Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes
Abstract
Recent epidemiologic studies have implicated genital/anorectal ulcer disease as an important cofactor for acquisition and transmission of human immunodeficiency virus (HIV) during sexual intercourse. To better understand the mechanism for the association between genital ulcers and HIV, exudates from 62 genital ulcers of 56 HIV-seropositive prostitutes in Nairobi (Kenya) were cultured for HIV. Twenty-six ulcer cultures could not be evaluated for the presence of HIV because of bacterial or fungal contamination. HIV was isolated from 4 (11%) of the 36 remaining uncontaminated ulcer cultures (2 introital, 1 vaginal, and 1 cervical) from 4 separate women. HIV was isolated from the cervical os from only 2 of the 4 women. HIV p24 antigen was detected in exudate from 1 of the 4 culture-positive ulcers and 0 of 32 culture-negative ulcers. Genital ulcers in seropositive patients should be regarded as potential sources of HIV, which could be important in transmission of HIV during intercourse. Public health measures aimed at controlling sexually transmitted genital ulcer diseases should be an integral part of acquired immunodeficiency syndrome (AIDS) prevention programs.
Similar articles
-
Condom use prevents genital ulcers in women working as prostitutes. Influence of human immunodeficiency virus infection.Sex Transm Dis. 1991 Jul-Sep;18(3):188-91. doi: 10.1097/00007435-199107000-00013. Sex Transm Dis. 1991. PMID: 1948518
-
Risk factors for genital ulcerations in Kenyan sex workers. The role of human immunodeficiency virus type 1 infection.Sex Transm Dis. 1997 Aug;24(7):387-92. doi: 10.1097/00007435-199708000-00001. Sex Transm Dis. 1997. PMID: 9263358
-
Nonoxynol-9 use, genital ulcers, and HIV infection in a cohort of sex workers.Genitourin Med. 1995 Apr;71(2):78-81. doi: 10.1136/sti.71.2.78. Genitourin Med. 1995. PMID: 7744418 Free PMC article.
-
Human immunodeficiency virus, genital ulcers and the male foreskin: synergism in HIV-1 transmission.Scand J Infect Dis Suppl. 1990;69:181-6. Scand J Infect Dis Suppl. 1990. PMID: 2263893 Review.
-
Genital ulcers, other sexually transmitted diseases, and the sexual transmission of HIV.BMJ. 1989 Mar 11;298(6674):623-4. doi: 10.1136/bmj.298.6674.623. BMJ. 1989. PMID: 2496785 Free PMC article. Review.
Cited by
-
The Diagnosis and Management of Syphilis in the HIV-Infected Patient.Curr Infect Dis Rep. 2000 Feb;2(1):10-13. doi: 10.1007/s11908-000-0081-1. Curr Infect Dis Rep. 2000. PMID: 11095831
-
Repertoire of chemokine receptor expression in the female genital tract: implications for human immunodeficiency virus transmission.Am J Pathol. 1998 Aug;153(2):481-90. doi: 10.1016/S0002-9440(10)65591-5. Am J Pathol. 1998. PMID: 9708808 Free PMC article.
-
2024 European guidelines for the management of genital herpes.J Eur Acad Dermatol Venereol. 2025 Apr;39(4):742-758. doi: 10.1111/jdv.20450. Epub 2024 Dec 2. J Eur Acad Dermatol Venereol. 2025. PMID: 39620271 Free PMC article.
-
Clinical and therapeutic issues for herpes simplex virus-2 and HIV co-infection.Drugs. 2007;67(2):155-74. doi: 10.2165/00003495-200767020-00001. Drugs. 2007. PMID: 17284082 Review.
-
Real-time PCR quantification of genital shedding of herpes simplex virus (HSV) and human immunodeficiency virus (HIV) in women coinfected with HSV and HIV.J Clin Microbiol. 2006 Feb;44(2):423-32. doi: 10.1128/JCM.44.2.423-432.2006. J Clin Microbiol. 2006. PMID: 16455895 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources