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Review
. 2016 Jul 28;22(28):6393-401.
doi: 10.3748/wjg.v22.i28.6393.

Hepatitis C virus: Promising discoveries and new treatments

Juliana Cristina Santiago Bastos  1 , Marina Aiello Padilla  1 , Leonardo Cardia Caserta  1 , Noelle Miotto  1 , Aline Gonzalez Vigani  1 , Clarice Weis Arns  1
Affiliations
Review

Hepatitis C virus: Promising discoveries and new treatments

Juliana Cristina Santiago Bastos et al. World J Gastroenterol. .

Abstract

Despite advances in therapy, hepatitis C virus (HCV) infection remains an important global health issue. It is estimated that a significant part of the world population is chronically infected with the virus, and many of those affected may develop cirrhosis or liver cancer. The virus shows considerable variability, a characteristic that directly interferes with disease treatment. The response to treatment varies according to HCV genotype and subtype. The continuous generation of variants (quasispecies) allows the virus to escape control by antivirals. Historically, the combination of ribavirin and interferon therapy has represented the only treatment option for the disease. Currently, several new treatment options are emerging and are available to a large part of the affected population. In addition, the search for new substances with antiviral activity against HCV continues, promising future improvements in treatment. Researchers should consider the mutation capacity of the virus and the other variables that affect treatment success.

Keywords: Antiviral research; Hepatitis C infection; Hepatitis C virus; Treatments.

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