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Review
. 2016 Aug;33(4):247-52.
doi: 10.5114/ada.2016.61599. Epub 2016 Aug 16.

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

Agnieszka Wasilewska  1 , Marta Winiarska  1 , Małgorzata Olszewska  1 , Lidia Rudnicka  1
Affiliations
Review

Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases

Agnieszka Wasilewska et al. Postepy Dermatol Alergol. 2016 Aug.

Abstract

Psoriasis is a chronic skin disease caused by the excessive secretion of inflammatory cytokines. Available therapeutic options include biologic drugs such as tumor necrosis factor alpha inhibitors and interleukin 12/23 (IL-12/23) inhibitors. The recent discovery of IL-17, which contributes to development of psoriasis, opened new possibilities for further treatment modalities. Currently, one anti-IL17 biological agent is approved for the treatment - a fully human monoclonal antibody that targets IL-17A (secukinumab). Further clinical trials, including a humanized IgG4 specific for IL-17 (ixekizumab) and a fully human antibody that targets the IL-17 receptor A (brodalumab).

Keywords: alopecia areata; fynomer; lichen planus; pemphigoid; pemphigus.

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