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Review
. 2016 Aug 9:5:F1000 Faculty Rev-1939.
doi: 10.12688/f1000research.8546.1. eCollection 2016.

Perinatal neuroprotection update

Angie C Jelin  1 , Kirsten Salmeen  2 , Dawn Gano  3 , Irina Burd  1 , Mari-Paule Thiet  2
Affiliations
Review

Perinatal neuroprotection update

Angie C Jelin et al. F1000Res. .

Abstract

Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm. We recently published a comprehensive review addressing the impacts of magnesium sulfate, therapeutic hypothermia, delayed cord clamping, infections, and prevention of preterm delivery on the modification of neurological risk [2]. In this review, we will briefly provide updates to the aforementioned topics as well as an expansion on avoidance of toxin and infections, specifically the Zika virus.

Keywords: Delayed umbilical cord clamping; Perinatal; Zika virus; neurological deficits; neuroprotection; preterm delivery.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

No competing interests were disclosed.

References

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