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Review
. 2016 Aug 24:4:37.
doi: 10.3389/fchem.2016.00037. eCollection 2016.

Adenosine A2B Receptor: From Cell Biology to Human Diseases

Ying Sun  1 , Pingbo Huang  2
Affiliations
Review

Adenosine A2B Receptor: From Cell Biology to Human Diseases

Ying Sun et al. Front Chem. .

Abstract

Extracellular adenosine is a ubiquitous signaling molecule that modulates a wide array of biological processes. Recently, significant advances have been made in our understanding of A2B adenosine receptor (A2BAR). In this review, we first summarize some of the general characteristics of A2BAR, and then we describe the multiple binding partners of the receptor, such as newly identified α-actinin-1 and p105, and discuss how these associated proteins could modulate A2BAR's functions, including certain seemingly paradoxical functions of the receptor. Growing evidence indicates a critical role of A2BAR in cancer, renal disease, and diabetes, in addition to its importance in the regulation of vascular diseases, and lung disease. Here, we also discuss the role of A2BAR in cancer, renal disease, and diabetes and the potential of the receptor as a target for treating these three diseases.

Keywords: A2B adenosine receptor; binding proteins; cancer; diabetes; renal disease.

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Figures

Figure 1
Figure 1
A2BAR binding partners and their cellular functions.
Figure 2
Figure 2
Schematic presentation of the role of A2BAR in various human diseases.
See this image and copyright information in PMC

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References

    1. Aherne C. M., Kewley E. M., Eltzschig H. K. (2011). The resurgence of A2B adenosine receptor signaling. Biochim. Biophys. Acta 1808, 1329–1339. 10.1016/j.bbamem.2010.05.016 - DOI - PMC - PubMed
    1. Andersson O. (2014). Role of adenosine signalling and metabolism in beta-cell regeneration. Exp. Cell Res. 321, 3–10. 10.1016/j.yexcr.2013.11.019 - DOI - PubMed
    1. Antonioli L., Blandizzi C., Csoka B., Pacher P., Hasko G. (2015). Adenosine signalling in diabetes mellitus–pathophysiology and therapeutic considerations. Nat. Rev. Endocrinol. 11, 228–241. 10.1038/nrendo.2015.10 - DOI - PubMed
    1. Arin R. M., Vallejo A. I., Rueda Y., Fresnedo O., Ochoa B. (2015). The A2B adenosine receptor colocalizes with adenosine deaminase in resting parietal cells from gastric mucosa. Biochem. Mosc. 80, 120–125. 10.1134/S0006297915010149 - DOI - PubMed
    1. Barkett M., Gilmore T. D. (1999). Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18, 6910–6924. 10.1038/sj.onc.1203238 - DOI - PubMed