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Case Reports
. 1989 Jul-Aug;26(4):159-61.
doi: 10.3928/0191-3913-19890701-03.

Neural misdirection in congenital ocular fibrosis syndrome: implications and pathogenesis

M C Brodsky  1 , S C Pollock, E G Buckley
Affiliations
Case Reports

Neural misdirection in congenital ocular fibrosis syndrome: implications and pathogenesis

M C Brodsky et al. J Pediatr Ophthalmol Strabismus. 1989 Jul-Aug.

Abstract

A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.

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Comment in

  • Congenital fibrosis syndrome.
    Simonsz HJ. Simonsz HJ. J Pediatr Ophthalmol Strabismus. 1990 Nov-Dec;27(6):328-9. doi: 10.3928/0191-3913-19901101-16. J Pediatr Ophthalmol Strabismus. 1990. PMID: 2086753 No abstract available.

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