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. 1989;9(1):44-7.
doi: 10.1007/BF02933743.

The effect of high cholesterol, high fat diet on rabbit plasma beta-VLDL and its interaction with macrophage

S P Wang, Z C Feng, Y M Feng, W S Wu, C B Wang, W G Jiang, W X Dai, J G Liang

The effect of high cholesterol, high fat diet on rabbit plasma beta-VLDL and its interaction with macrophage

S P Wang et al. J Tongji Med Univ. 1989.

Abstract

Rabbits were fed on 1% cholesterol and 10% rape seed oil (group A) or lard (group B). Plasma cholesterol and triglyceride level of group A was strikingly lower than that of group B. No difference was found in the lipid composition of beta-VLDLs between both groups. However, apo E content of beta-VLDL from group A was higher and apo B (higher molecular weight) was lower than that of group B respectively. beta-VLDL of group A caused greater accumulation of cholesterol in mouse peritoneal macrophage than that of group B. Therefore, we assume that the good effect of poly-unsaturated fatty acid on atherosclerosis results not from decreasing accumulation of cholesterol in macrophages but from enhancing elimination of beta-VLDL by the liver.

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