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. 1989 Sep;63(9):3678-82.
doi: 10.1128/JVI.63.9.3678-3682.1989.

Identification of two murine loci homologous to the v-cbl oncogene

D C Regnier  1 , C A Kozak, D M Kingsley, N A Jenkins, N G Copeland, W Y Langdon, H C Morse 3rd
Affiliations

Identification of two murine loci homologous to the v-cbl oncogene

D C Regnier et al. J Virol. 1989 Sep.

Abstract

The virally transduced oncogene v-cbl transforms fibroblasts in vitro and induces early B-cell-lineage lymphomas in vivo. A series of probes derived from a molecular clone of v-cbl were used to map related sequences in the mouse genome. Analyses of Chinese hamster x mouse somatic-cell hybrids showed that two related genes, cbl-1 and cbl-2, were located on chromosomes 6 and 9, respectively. Restriction enzyme studies of DNA from hybrid cells containing either chromosome 6 or 9 suggested that cbl-1 resembles v-cbl and may be a processed gene, whereas cbl-2 has a complex genomic structure. Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1.

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References

    1. Nature. 1984 Aug 16-22;310(5978):581-3 - PubMed
    1. Immunogenetics. 1987;26(4-5):258-66 - PubMed
    1. Cell. 1985 Aug;42(1):23-38 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5832-5 - PubMed
    1. Immunogenetics. 1985;22(3):277-83 - PubMed

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