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. 2016 Sep 8;6(9):e011939.
doi: 10.1136/bmjopen-2016-011939.

Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study

Huili Wei  1 , Hua Qu  1 , Hang Wang  1 , Huacong Deng  1
Affiliations

Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study

Huili Wei et al. BMJ Open. .

Abstract

Objectives: Various studies have revealed a close association between sedentary behaviour and metabolic diseases, yet the association between sedentary time and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we investigated the association between sitting time and NAFLD in a Chinese male population and explored its underlying mechanism.

Study design: A cross-sectional study.

Setting: Chongqing, China.

Participants: Our study included 2054 male participants; all of the participants were of Han nationality.

Primary outcome measures: Sitting time was assessed using a self-reported questionnaire concerning the time devoted to sitting behaviour. Various clinical and demographic biomarkers were measured. Logistic regression analyses were used to investigate the ORs and the 95% CIs between sitting time and NAFLD.

Results: We found a higher proportion of NAFLD across the tertiles of sitting time (p trend=0.003). Multivariate linear regression analyses showed sitting time independently correlated with homoeostasis model assessment for insulin resistance (HOMA-IR), alanine aminotransferase, γ-glutamyl transpeptidase, body mass index, triglyceride and the high-sensitive C reactive protein (hsCRP) (all p<0.05). Further logistic regression analyses showed that longer sitting time (>7.1 hours/day) was associated with a higher prevalence of NAFLD (OR 1.09; 95% CI (1.04 to 1.67)) after adjusting for confounders. However, this association was insignificant after further adjusting for hsCRP (OR 1.03; 95% CI (0.92 to 1.84)).

Conclusions: Sitting time was positively associated with the prevalence of NAFLD, and this association might be affected by inflammation.

Keywords: Non-alcoholic fatty liver disease; inflammation; sitting time.

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References

    1. Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science 2011;332:1519–23. 10.1126/science.1204265 - DOI - PMC - PubMed
    1. Goh GB, McCullough AJ. Natural History of Nonalcoholic Fatty Liver Disease. Dig Dis Sci 2016;61:1226–33. 10.1007/s10620-016-4095-4 - DOI - PMC - PubMed
    1. Ray K. NAFLD-the next global epidemic. Nat Rev Gastroenterol Hepatol 2013;10:621 10.1038/nrgastro.2013.197 - DOI - PubMed
    1. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol 2009;50:204–10. 10.1016/j.jhep.2008.10.010 - DOI - PubMed
    1. Zhang Y, Zhang T, Zhang C et al. . Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population. BMJ Open 2015;5:e008204 10.1136/bmjopen-2015-008204 - DOI - PMC - PubMed