Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat
- PMID: 27610563
- DOI: 10.1016/j.cell.2016.08.034
Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat
Abstract
The reprioritization of feeding motivations during disease is proposed to optimize host defense strategies against infection. Now, Wang et al. identify that sickness-induced anorexia differentially shapes the metabolic requirements of cellular stress adaptations, leading to opposite impact on disease tolerance upon bacterial versus viral infections.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026. Cell. 2016. PMID: 27610573 Free PMC article.
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