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. 2016 Dec 1;8(4):439-444.
doi: 10.4274/jcrpe.3498. Epub 2016 Sep 9.

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

Erdoğan Özgür  1 , Börte Gürbüz Özgür, Hatice Aksu, Gökhan Cesur
Affiliations

The Effect of Congenital and Postnatal Hypothyroidism on Depression-Like Behaviors in Juvenile Rats

Erdoğan Özgür et al. J Clin Res Pediatr Endocrinol. .

Abstract

Objective: The aim of this study was to investigate depression-like behaviors of juvenile rats with congenital and postnatal hypothyroidism.

Methods: Twenty-seven newborn rat pups were used. First, 6-month-old Wistar Albino female rats were impregnated. Methimazole (0.025% wt/vol) was given to dam rats from the first day of pregnancy until postnatal 21 days (P21) to generate pups with congenital hypothyroidism (n=8), whereas in the postnatal hypothyroidism group (n=10), methimazole was given from P0 to P21. In the control group (n=9), dam rats were fed ad libitum and normal tap water. Offspring were fed with breast milk from their mothers. The behavioral parameters were measured with the juvenile forced swimming test (JFST). The procedure of JFST consisted of two sessions in two consecutive days: the 15-minute pre-test on day 1 and the 5-minute test on day 2.

Results: Increased immobility and decreased climbing duration were observed in both congenital and postnatal hypothyroidism groups. Decreased swimming duration was detected in the postnatal hypothyroidism group. Both hypothyroidism groups had a lower body weight gain compared with the control group, while the congenital hypothyroidism group had the lowest body weight.

Conclusion: Our results showed that hypothyroidism had negative effects on depression-like behavior as well as on growth and development. Both congenital and postnatal hypothyroidism caused an increase in immobility time in JFST. New studies are required to understand the differing results on depression-like behavior between congenital and postnatal hypothyroidism.

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Conflict of interest statement

Financial Disclosure: The authors declared that this study received no financial support.

Figures

Figure 1
Figure 1. Duration of immobility
Figure 2
Figure 2. Duration of swimming
Figure 3
Figure 3. Duration of climbing
See this image and copyright information in PMC

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References

    1. Taşkın E, Artis AS, Bitiktas S, Dolu N, Liman N, Süer C. Experimentally induced hyperthyroidism disrupts hippocampal long-term potentiation in adult rats. Neuroendocrinology. 2011;94:218–227. - PubMed
    1. Samuels MH, Schuff KG, Carlson NE, Carello P, Janowsky JS. Health status, mood, and cognition in experimentally induced subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92:2545–2551. - PubMed
    1. SM S. Stahl’s Essential Psychopharmacology. 3 rd ed. New York: Cambridge University Press; 2008. pp. 511–666.
    1. Christian MS, Trenton NA. Evaluation of thyroid function in neonatal and adult rats: The neglected endocrine mode of action. Pure Appl Chem. 2003;75:2055–2068.
    1. Dugbartey AT. Neurocognitive aspects of hypothyroidism. Arch Intern Med. 1998;158:1413–1418. - PubMed

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