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. 2016 Nov;138(5):1436-1439.e11.
doi: 10.1016/j.jaci.2016.06.030. Epub 2016 Sep 6.

Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies

Ludmila Perelygina  1 , Stanley Plotkin  2 , Pierre Russo  3 , Timo Hautala  4 , Francisco Bonilla  5 , Hans D Ochs  6 , Avni Joshi  7 , John Routes  8 , Kiran Patel  9 , Claudia Wehr  10 , Joseph Icenogle  1 , Kathleen E Sullivan  11
Affiliations

Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies

Ludmila Perelygina et al. J Allergy Clin Immunol. 2016 Nov.
No abstract available

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Conflict of interest statement

Disclosure of potential conflict of interest: The rest of the authors declare that they have no relevant conflicts of interest.

Figures

FIG 1
FIG 1
Cutaneous granulomas in patients. A, Hematoxylin and eosin staining of a cutaneous granuloma from case 1. A well-formed granuloma is centrally located. B and C, Cutaneous skin lesions from case 3. Acute and chronic ulcers are observed. D–F, Distribution of RV-infected cells in skin samples of patients with PID. Histological immunofluorescent staining showing focal (Fig 1, D, case 1) or widespread (Fig 1, E, case 2) distribution of RV capsid in granulomas and focal capsid localization in the epidermis (Fig 1, F, case 5). Activation status of macrophages in granulomas (G–I, case 6). Double immunofluorescent staining of granulomas with RV capsid antibody (red) and M2 macrophage-specific antibodies, CD206 (Fig 1, G, green) or CD163 (Fig 1, H, green). I, RV antigen expression in the suprabasal cell layer of skin epidermis (case 1). Double immunofluorescent staining with RV capsid antibody (red) and keratinocyte-specific antibody (cytokeratin, green). Nuclei were counterstained with DAPI. DAPI, 4′-6-Diamidino-2-phenylindole, dihydrochloride; RV-C, rubella virus capsid.
See this image and copyright information in PMC

References

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